Principal Investigator: Rebecca Levy, MD, FRCPCHospital for Sick Children, Toronto Overview: Hematopoietic stem cell transplantation (HSCT) is a procedure used to cure a variety of potentially fatal diseases, including cancers and genetic conditions. For HSCT survivors, we now understand … [Read more...] about Characterizing the Cutaneous Late Effects in Pediatric Hematopoietic Stem Cell Transplantation Recipients
Skin Tumors and Reactions to Cancer Therapies
Noninvasive Molecular Diagnostic Tests for Pediatric Pigmented Lesions
Principal Investigator: Elena Hawryluk, MD, PhDMassachusetts General Hospital Overview: This research proposal seeks to better understand moles in children: features that may prompt concern for a skin biopsy, and the natural characteristics of nevi from patients with diverse skin … [Read more...] about Noninvasive Molecular Diagnostic Tests for Pediatric Pigmented Lesions
A Multi-Center Retrospective Cohort Study on the Utility of Ancillary Studies in the Risk Assessment and Management of Spitz Nevi, Atypical Spitzoid Tumors, and Spitzoid Melanoma in the Pediatric Population
Principal Investigator: Kristen Berrebi, MDUniversity of Iowa Health Care Overview: Spitz tumors are melanocytic proliferations seen in children and are divided into three categories along a spectrum: (1) benign Spitz nevus, (2) atypical Spitz tumor, and (3) Spitzoid melanoma. The current … [Read more...] about A Multi-Center Retrospective Cohort Study on the Utility of Ancillary Studies in the Risk Assessment and Management of Spitz Nevi, Atypical Spitzoid Tumors, and Spitzoid Melanoma in the Pediatric Population
Beyond the phenotype – A targeted sequencing study to identify the spectrum of genetic mutations in pyogenic granulomas
Principal Investigator: Carrie Coughlin, MDWashington University School of Medicine in St. Louis Overview: Pyogenic granulomas are benign growths of blood vessels which can grow quickly and bleed. It can be difficult to stop the bleeding, which can make them an urgent problem. Their primary … [Read more...] about Beyond the phenotype – A targeted sequencing study to identify the spectrum of genetic mutations in pyogenic granulomas
Keratinocyte Carcinoma in Pediatric Solid Organ Transplant Patients
Fellow Muskaan Sachdeva, BHScUniversity of Toronto Mentor Cathryn Sibbald, MScPhm, MD, FRCPC, MScUniversity of TorontoThe Hospital for Sick Children Overview Keratinocyte carcinomas (KC), which include basal cell and squamous cell carcinomas, are the most common malignancy in organ … [Read more...] about Keratinocyte Carcinoma in Pediatric Solid Organ Transplant Patients
The impact of dilute bleach compresses on the incidence and severity of radiation dermatitis
Fellow Danny Linggonegoro Harvard Medical School Mentor Jennifer Huang, MD Harvard Medical School Overview Acute radiation skin toxicity is one of the most common side effects encountered in those undergoing radiation therapy, affecting nearly all patients; however, no standard criterion … [Read more...] about The impact of dilute bleach compresses on the incidence and severity of radiation dermatitis
Preventative Skin Care for Children Undergoing Targeted CNS Tumor Therapy
Principal Investigator: Jennifer Huang, MDBoston Children's Hospital Overview: Cancer treatments targeting MEK and BRAF proteins are used to treat childhood brain tumors. Treatments can often cause cutaneous problems, sometimes leading to discontinuation of life-saving treatments. Our study … [Read more...] about Preventative Skin Care for Children Undergoing Targeted CNS Tumor Therapy
What does a pediatric BAP1 inactivated melanocytic tumor (BIMT) look like?
Principal Investigator: Elena Hawryluk, MD, PhD Massachusetts General Hospital Overview: Spitz nevi are a type of skin growth that occur most commonly in children. This study seeks to better understand Spitz nevi in children by determining possible overlap with a different entity known as … [Read more...] about What does a pediatric BAP1 inactivated melanocytic tumor (BIMT) look like?
