Keratinocyte Carcinoma in Pediatric Solid Organ Transplant Patients

Overview

Keratinocyte carcinomas (KC), which include basal cell and squamous cell carcinomas, are the most common malignancy in organ transplant recipients. Specifically, the incidence of basal cell carcinoma is 10 times higher, and squamous cell carcinoma is 100 times more frequent in adult transplant recipients than the general population. Although the success of transplants has vastly improved for children, limited research exists on the risk of post-transplant KC in pediatric populations, with a recent study excluding these cancers. Pediatric transplant patients are immunocompromised for longer durations than patients transplanted in adulthood, and therefore the onset of KC in pediatric transplant recipients may occur at an earlier age. Analysis of specific pediatric data is important to fully quantify and understand the risk of KC in this population.

Status

This project was funded through a 2020 PeDRA Research Fellowship Grant.