PeDRA

Pediatric Dermatology Research Alliance

Connective Tissue & Autoimmune

Optimizing Clinical Application of Lymphocyte Activation Tests for the Detection of Causative Medications in severe cutaneous Adverse Reactions

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Principal Investigator: Reid Oldenburg, MD, PhDUniversity of California, San Diego Overview: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are catastrophic drug reactions that destroy the skin, surface of the eyes and lining of the mouth and genitals. Antibiotics, … [Read more...] about Optimizing Clinical Application of Lymphocyte Activation Tests for the Detection of Causative Medications in severe cutaneous Adverse Reactions

Characterization of the presenting cutaneous manifestations of juvenile dermatomyositis

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Principal Investigator: Sonia Kamath, MDChildren's Hospital Los Angeles Keck School of Medicine of the University of Southern California (USC) Overview: Juvenile dermatomyositis (JDM) is a rare autoimmune disease, causing muscle weakness and rash. The skin findings are variable and are … [Read more...] about Characterization of the presenting cutaneous manifestations of juvenile dermatomyositis

Investigating Constitutive and Cell-Driven Fibroblast Activation in Pediatric Morphea

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Fellow Laila AbbasUT Southwestern Medical Center Mentor Heidi Jacobe, MD, MSCSUT Southwestern Medical Center Overview Morphea, or localized scleroderma, is a neglected autoimmune disease of the skin and underlying tissue that produces permanent disability due to joint contracture and soft … [Read more...] about Investigating Constitutive and Cell-Driven Fibroblast Activation in Pediatric Morphea

Genetic Variations in Non-coding Regulatory Regions in Linear Morphea

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Principal Investigator: Dawn Eichenfield, MD, PhD University of California, San Diego Overview: Morphea is an inflammatory skin condition leading to hardened, discolored, and ultimately, scarred skin. It has several different presentations. Linear morphea commonly appears in children as a … [Read more...] about Genetic Variations in Non-coding Regulatory Regions in Linear Morphea

Sun Protection for Pediatric Rheumatology Patients

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Principal Investigator: Irene Lara-Corrales, MD University of Toronto Overview: This is a survey study in collaboration with the Childhood Arthritis and Rheumatology Research Alliance (CARRA). Pediatric rheumatologists and pediatric rheumatology patients will be surveyed about the sun … [Read more...] about Sun Protection for Pediatric Rheumatology Patients

North American Study of Pediatric Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: Setting Diagnostic Criteria, Systematic Review and Retrospective Cohort Analysis Comparing Outcomes of Common Treatments

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Principal Investigator: Michele Ramien, MD University of Calgary Overview: A critical gap exists in our knowledge of Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) in pediatrics. Little is known about how to accurately define the spectrum of disease or direct optimal … [Read more...] about North American Study of Pediatric Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: Setting Diagnostic Criteria, Systematic Review and Retrospective Cohort Analysis Comparing Outcomes of Common Treatments

Longitudinal Characterization of Pediatric Morphea

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Principal Investigator: Yvonne Chiu, MD Medical College of Wisconsin Overview: This is a national clinical registry and DNA biobank of pediatric morphea. The goal is to define the natural history of pediatric-onset morphea and identify genes and pathways involved in its development. … [Read more...] about Longitudinal Characterization of Pediatric Morphea