Fellow Laila AbbasUT Southwestern Medical Center Mentor Heidi Jacobe, MD, MSCSUT Southwestern Medical Center Overview Morphea, or localized scleroderma, is a neglected autoimmune disease of the skin and underlying tissue that produces permanent disability due to joint contracture and soft … [Read more...] about Investigating Constitutive and Cell-Driven Fibroblast Activation in Pediatric Morphea
Connective Tissue & Autoimmune
Genetic Variations in Non-coding Regulatory Regions in Linear Morphea
Principal Investigator: Dawn Eichenfield, MD, PhD University of California, San Diego Overview: Morphea is an inflammatory skin condition leading to hardened, discolored, and ultimately, scarred skin. It has several different presentations. Linear morphea commonly appears in children as a … [Read more...] about Genetic Variations in Non-coding Regulatory Regions in Linear Morphea
Sun Protection for Pediatric Rheumatology Patients
Principal Investigator: Irene Lara-Corrales, MD University of Toronto Overview: This is a survey study in collaboration with the Childhood Arthritis and Rheumatology Research Alliance (CARRA). Pediatric rheumatologists and pediatric rheumatology patients will be surveyed about the sun … [Read more...] about Sun Protection for Pediatric Rheumatology Patients
North American Study of Pediatric Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: Setting Diagnostic Criteria, Systematic Review and Retrospective Cohort Analysis Comparing Outcomes of Common Treatments
Principal Investigator: Michele Ramien, MD University of Calgary Overview: A critical gap exists in our knowledge of Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) in pediatrics. Little is known about how to accurately define the spectrum of disease or direct optimal … [Read more...] about North American Study of Pediatric Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: Setting Diagnostic Criteria, Systematic Review and Retrospective Cohort Analysis Comparing Outcomes of Common Treatments
Mapping Morphea: Toward a Better Understanding
Principal Investigator: Yvonne Chiu, MD Medical College of Wisconsin Overview: This is a retrospective chart and photograph review study conducted at seventeen collaborating sites. Using software initially developed for the Hemangioma Investigator Group, investigators have mapped morphea … [Read more...] about Mapping Morphea: Toward a Better Understanding
Longitudinal Characterization of Pediatric Morphea
Principal Investigator: Yvonne Chiu, MD Medical College of Wisconsin Overview: This is a national clinical registry and DNA biobank of pediatric morphea. The goal is to define the natural history of pediatric-onset morphea and identify genes and pathways involved in its development. … [Read more...] about Longitudinal Characterization of Pediatric Morphea
Investigation of Pediatric Onset Discoid Lupus
Principal Investigator: Lisa Arkin, MD University of Wisconsin Overview: This is a multi-centered, retrospective cohort study of pediatric patients with discoid lupus erythematosus (DLE). The primary aims are to: 1. Determine the cross-sectional characteristics of pediatric patients … [Read more...] about Investigation of Pediatric Onset Discoid Lupus
Developing an Outcome Measure for Morphea Disease Activity
Co-Principal Investigators: Maria Teresa Garcia Romero, MD, MPHNational Institute of Pediatrics, Mexico City Yvonne Chiu, MD Medical College of Wisconsin Overview: Morphea is a complex condition that mainly affects children and lacks a good way to measure disease activity. This … [Read more...] about Developing an Outcome Measure for Morphea Disease Activity
