PeDRA

Pediatric Dermatology Research Alliance

Active Studies

T regulatory cell dysfunction and Staphylococcus aureus infection enable atopic dermatitis onset and progression

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Principal Investigator: Hazel Wilkie, PhD Boston Children's Hospital Overview: Atopic dermatitis (AD, also called allergic eczema) affects 20% of children and 10% of adults. The dry, red, itchy skin lesions are often infected with bacteria. Intriguingly, skin bacterial burden increases prior … [Read more...] about T regulatory cell dysfunction and Staphylococcus aureus infection enable atopic dermatitis onset and progression

Childhood Atopic Dermatitis: The Role of Outdoor Air Pollution on Disease Burden and Racial and Ethnic Disparities

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Principal Investigator: Emily Croce, PhD, MSN, ADPRN, NPNP-CP The University of Texas at Austin Overview: Atopic dermatitis (AD) is the most common chronic childhood skin disease and there are significant and persistent racial and ethnic disparities in atopic dermatitis (AD) among children … [Read more...] about Childhood Atopic Dermatitis: The Role of Outdoor Air Pollution on Disease Burden and Racial and Ethnic Disparities

Post-Market Surveillance of the Safety of Systemic JAK Inhibitors for Dermatologic Diseases in Children

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Principal Investigator: Jeff Yu, MD Massachusetts General Hospital Overview: Oral Janus Kinase inhibitors (JAKi) are novel therapeutic options for patients with various inflammatory skin conditions, such as alopecia areata, atopic dermatitis, and psoriasis. Currently, most of the data that … [Read more...] about Post-Market Surveillance of the Safety of Systemic JAK Inhibitors for Dermatologic Diseases in Children

Neonatal Cutaneous Microbiome Predictors of Infantile Eczema

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Principal Investigator: Jennifer Schoch, MD University of Florida Overview: Though the cause of eczema is yet unknown, animal studies suggest importance of the early interaction between bacteria present on the skin and the immune system. If bacteria are present on the skin of mice shortly … [Read more...] about Neonatal Cutaneous Microbiome Predictors of Infantile Eczema

Characterization of Lipoprotein Composition and Function in Pediatric Psoriasis Before and After Treatment

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Principal Investigator: Amy Paller, MDNorthwestern University Overview: Psoriasis is a chronic inflammatory skin disease associated with early onset cardiovascular disease. Despite studies demonstrating high cholesterol, increased diabetes and higher rate of obesity in psoriasis, these … [Read more...] about Characterization of Lipoprotein Composition and Function in Pediatric Psoriasis Before and After Treatment

Understanding Racial/Ethnic Disparities in Health Care Utilization for Childhood Atopic Dermatitis

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Principal Investigator: Junko Takeshita, MD, PhD, MSCEUniversity of Pennsylvania Overview: Atopic dermatitis (AD) is a common skin disease that disproportionately affects minority children and is associated with a large financial burden in the U.S. Racial/ethnic disparities in health care … [Read more...] about Understanding Racial/Ethnic Disparities in Health Care Utilization for Childhood Atopic Dermatitis

Quality of Life of Parents with Children with Alopecia Areata

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Principal Investigator: Leslie Castelo-Soccio, MD, PhD Children's Hospital of Philadelphia Overview: Alopecia areata (AA) is an autoimmune disease resulting in non-scarring hair loss of hair-bearing areas, most frequently the scalp with a lifetime incidence of 1-2%. There is no sex … [Read more...] about Quality of Life of Parents with Children with Alopecia Areata