Michele Ramien, MD
University of Calgary
A critical gap exists in our knowledge of Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) in pediatrics. Little is known about how to accurately define the spectrum of disease or direct optimal treatment. Much of the literature we rely on to manage pediatric SJS and TEN (SJS/TEN) is extrapolated from adult studies, the applicability of which has been questioned in recent reviews. Discussion at the 2015 and 2016 PeDRA meetings with opinion leaders supports our proposal that diagnostic criteria are a critical first step to inform more detailed examination of pediatric SJS/TEN and advance clinical care.
We have three objectives:
1. Create consensus diagnostic criteria for the pediatric SJS/TEN spectrum using a combination of nominal group technique and the Delphi method;
2. Perform a systematic review of treatment responses in SJS/TEN;
3. Apply diagnostic criteria for a multicentre retrospective cohort analysis to determine optimal management and encourage standardized treatment.
This study was funded as a 2016 SPD-PeDRA Team Grant and is underway. The first of three anticipated publications is currently under review.