Connective Tissue & Autoimmune

Principal Investigator: Yvonne Chiu, MDMedical College of Wisconsin Overview: Morphea is a disease that causes issues in the skin, muscles, bones, and other body parts. It has two phases: an active phase and an inactive phase. Detecting whether morphea is active is difficult but important. … [Read more...] about Development of the Morphea Activity and Damage Measure (MADM)

Mentee Cheri Chambers, PhDUniversity of Washington Mentor Heather Brandling-Bennett, MDSeattle Children's Hospital University of Washington Overview Pediatric morphea is a chronic medical condition that can cause irreversible skin, muscle, and bone damage during development. Morphea affects … [Read more...] about Imaging Analysis of Facial Atrophy in Patients with Pediatric Morphea

Fellow Jessica CrockettUniversity of California, San Francisco Mentor Kelly Cordoro, MDUniversity of California, San Francisco Overview Pediatric autoimmune diseases cause significant morbidity from the conditions themselves and their treatment. Juvenile dermatomyositis (JDM) is a … [Read more...] about Pediatric Autoimmune Disease: Comprehensive Characterization of a Rheumatology-Dermatology Cohort and Prospective Registry Development

Fellow Jennifer SuiUC San Diego School of Medicine Mentor Dawn Eichenfield, MD, PhDUC San Diego School of Medicine Overview Linear morphea is a skin disease that causes hardened, discolored bands on the skin. Though this disease is relatively uncommon, it usually affects children and can … [Read more...] about Characterization of non-coding genetic loci and transcription factors that drive development of linear morphea

Principal Investigator: Sonia Kamath, MDChildren's Hospital Los Angeles Keck School of Medicine of the University of Southern California (USC) Overview: Juvenile dermatomyositis (JDM) is a rare autoimmune disease, causing muscle weakness and rash. The skin findings are variable and are … [Read more...] about Characterization of the presenting cutaneous manifestations of juvenile dermatomyositis

Fellow Henry ChenUT Southwestern Medical Center Mentor Heidi Jacobe MD, MSCSUT Southwestern Medical Center Overview Morphea, or localized scleroderma, is an idiopathic disorder of the skin and underlying tissue that produces permanent disability and functional impairment due to joint … [Read more...] about Identifying Dysregulated Immune-Related Gene Networks at the Single-Cell Level in Pediatric Morphea

Principal Investigator: Reid Oldenburg, MD, PhDUniversity of California, San Diego Overview: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are catastrophic drug reactions that destroy the skin, surface of the eyes and lining of the mouth and genitals. Antibiotics, … [Read more...] about Optimizing Clinical Application of Lymphocyte Activation Tests for the Detection of Causative Medications in severe cutaneous Adverse Reactions

Principal Investigator: Sonia Kamath, MDChildren's Hospital Los Angeles Keck School of Medicine of the University of Southern California (USC) Overview: Juvenile dermatomyositis (JDM) is a rare autoimmune disease, causing muscle weakness and rash. The skin findings are variable and are … [Read more...] about Characterization of the presenting cutaneous manifestations of juvenile dermatomyositis