Characterization of non-coding genetic loci and transcription factors that drive development of linear morphea

Overview

Linear morphea is a skin disease that causes hardened, discolored bands on the skin. Though this disease is relatively uncommon, it usually affects children and can lead to significant deformities and disabilities when the child’s face, scalp, or joints are affected. The cause of linear morphea is not yet known. It is thought to be an immune disease that is affected by many factors, including the information contained in our genes. The purpose of this study is to help us understand what exactly in certain people’s genes causes them to develop linear morphea. We will use scientific tools to compare the DNA, and molecules that interact with DNA, in affected versus normal skin of children with linear morphea. We will also determine what effects these differences have on skin cells. By doing this, we will be able to better understand the disease and create more effective ways to treat it.

Status

This project was funded through a 2022 PeDRA Research Fellowship Grant.