Principal Investigator: Maranke Koster, PhDEast Carolina University, Brody School of Medicine Overview: Patients affected by TP63-related ectodermal dysplasias (AEC & EEC) suffer from skin erosions, large wounds that do not heal normally. In many patients, healing of these large erosions … [Read more...] about Wound healing dynamics in ectodermal dysplasias
Active Studies
Genetic Landscape of Pediatric Patients with Monogenic Susceptibilities to Atopic Dermatitis
Principal Investigator: Hassan Vahidnezhad, MSc, PhD Children's Hospital of Philadelphia Overview: Childhood eczema, also called atopic dermatitis (AD), is the most common skin disease in children, is characterized by inflammation and itching, and is often associated with a history of atopy … [Read more...] about Genetic Landscape of Pediatric Patients with Monogenic Susceptibilities to Atopic Dermatitis
T regulatory cell dysfunction and Staphylococcus aureus infection enable atopic dermatitis onset and progression
Principal Investigator: Hazel Wilkie, PhD Boston Children's Hospital Overview: Atopic dermatitis (AD, also called allergic eczema) affects 20% of children and 10% of adults. The dry, red, itchy skin lesions are often infected with bacteria. Intriguingly, skin bacterial burden increases prior … [Read more...] about T regulatory cell dysfunction and Staphylococcus aureus infection enable atopic dermatitis onset and progression
Childhood Atopic Dermatitis: The Role of Outdoor Air Pollution on Disease Burden and Racial and Ethnic Disparities
Principal Investigator: Emily Croce, PhD, MSN, ADPRN, NPNP-CP The University of Texas at Austin Overview: Atopic dermatitis (AD) is the most common chronic childhood skin disease and there are significant and persistent racial and ethnic disparities in atopic dermatitis (AD) among children … [Read more...] about Childhood Atopic Dermatitis: The Role of Outdoor Air Pollution on Disease Burden and Racial and Ethnic Disparities
Post-Market Surveillance of the Safety of Systemic JAK Inhibitors for Dermatologic Diseases in Children
Principal Investigator: Jeff Yu, MD Massachusetts General Hospital Overview: Oral Janus Kinase inhibitors (JAKi) are novel therapeutic options for patients with various inflammatory skin conditions, such as alopecia areata, atopic dermatitis, and psoriasis. Currently, most of the data that … [Read more...] about Post-Market Surveillance of the Safety of Systemic JAK Inhibitors for Dermatologic Diseases in Children
Neonatal Cutaneous Microbiome Predictors of Infantile Eczema
Principal Investigator: Jennifer Schoch, MD University of Florida Overview: Though the cause of eczema is yet unknown, animal studies suggest importance of the early interaction between bacteria present on the skin and the immune system. If bacteria are present on the skin of mice shortly … [Read more...] about Neonatal Cutaneous Microbiome Predictors of Infantile Eczema
Characterization of Lipoprotein Composition and Function in Pediatric Psoriasis Before and After Treatment
Principal Investigator: Amy Paller, MDNorthwestern University Overview: Psoriasis is a chronic inflammatory skin disease associated with early onset cardiovascular disease. Despite studies demonstrating high cholesterol, increased diabetes and higher rate of obesity in psoriasis, these … [Read more...] about Characterization of Lipoprotein Composition and Function in Pediatric Psoriasis Before and After Treatment
Understanding Racial/Ethnic Disparities in Health Care Utilization for Childhood Atopic Dermatitis
Principal Investigator: Junko Takeshita, MD, PhD, MSCEUniversity of Pennsylvania Overview: Atopic dermatitis (AD) is a common skin disease that disproportionately affects minority children and is associated with a large financial burden in the U.S. Racial/ethnic disparities in health care … [Read more...] about Understanding Racial/Ethnic Disparities in Health Care Utilization for Childhood Atopic Dermatitis
