Non-Invasive Genomic Testing of Large and Giant Congenital Nevi

Overview

My project, “Noninvasive Genomic Testing of Large and Giant Congenital Melanocytic Nevi,” aims to determine if a tape test on the skin surface can reliably rule out melanoma development in children with birthmarks larger than 20 centimeters. This technology, effective in adults, remains untested in children. The tape test collects the top skin layer, analyzing genetic “messages” for melanoma suspicion or benign characteristics. We’ll collect 100 tape samples (5 each from 20 children) to assess these birthmarks. We anticipate distinct genetic messages in benign birthmarks compared to those prone to melanoma in adults. Sampling benign birthmarks over time can reassure children and caregivers, reducing painful skin tests and alleviating parental stress. This research holds promise for pediatric dermatology, offering a less invasive approach to monitoring birthmarks in children.

Status

This project was funded through a 2024 PeDRA Emerging Investigator Research Grant.