Yvonne Chiu, MD
Medical College of Wisconsin
Michele Ramien, MD
University of Calgary
Beth Drolet, MD
University of Wisconsin, Madison
Reactive infectious mucocutaneous eruption (RIME) is a condition activated by an infection, resulting in blisters on the skin and widespread sores on mucous membranes. RIME is rare but most commonly affects children and adolescents. Recurrent RIME, where people have multiple episodes of RIME, is even more rare.
Recent research studies have shown that genetic differences can affect how children respond to common viral infections. We hypothesize that people who have RIME have genetic differences that cause an abnormal hyper-inflammatory response to common infections, and that people with recurrent RIME have even stronger genetic susceptibility.
The medical community does not know much about RIME or how to treat it. We would like to characterize RIME and recurrent RIME, describing the clinical features, the immunologic profile, and discovering genetic variants. We hope that if we can understand what makes children have RIME, we will be able to treat the disease more effectively.
This project was funded by a 2020 PeDRA Research Grant.