Clinical and Immunologic Characterization of Very Early-Onset Alopecia Areata: Identifying Underlying Inborn Errors of Immunity
University of Washington School of Medicine
Children’s National Hospital
Overview:
Alopecia areata (AA) is a condition that causes hair loss. While most cases affect only the skin, some children who develop AA very early in life, especially before age four, may have an underlying immune system problem. In some cases, early hair loss may be the first visible sign of a broader immune disorder.
We hypothesize that children with very early-onset AA are more likely to have immune abnormalities and genetic changes affecting immune regulation than children who develop AA later in life.
To better understand this, we will evaluate children with AA over time, reviewing their medical history, immune and genetic testing when available, and responses to treatment. Our goal is to identify which children may benefit from additional immune evaluation and closer monitoring.
This research aims to support earlier diagnosis, guide more personalized care, and improve long-term outcomes for children and their families.
Status:
This was funded through a 2026 PeDRA Research Fellowship Grant. Anna Ujváry was selected as the 2026 Founders’ Fellow, funded by individual donors and the PeDRA Board of Directors, who also supported an additional 2026 Research Fellowship through the 2025 end-of-year campaign.