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Three PeDRA Members Receive 2020 Research Awards from the Dermatology Foundation

March 24, 2020 By Jenn Dawson

March 24, 2020 – The pediatric dermatology community is proud to recognize three PeDRA members as recipients of 2020 Research Awards from the Dermatology Foundation.  Lisa Arkin, MD of the University of Wisconsin received a Pediatric Dermatology Career Development Award for a project titled Towards a Precision-based Treatment for Facial Vascular Stains, Leo Shmuylovich, MD, PhD of Washington University received a Dermatologist Investigator Research Fellowship to study Laser Stimulated Thermal Imaging of Nonmelanoma Skin Cancer, andJoy Wan, MD, MSCE of the University of Pennsylvania received a Career Development Award for a project titled Neurocognitive Functioning of Children with Atopic Dermatitis. 

Together with Elena Hawryluk, MD, PhD (Pediatric Dermatology Career Development Award, year 3) and Jeff Yu, MD (Pediatric Dermatology Career Development Award, year 2), this brings the total of active Dermatology Foundation-funded PeDRA members to five, and impacts projects spanning three of PeDRA’s five working groups. 

Visit the Dermatology Foundation website for information on all Research Awards granted in 2020 and to learn more about future funding opportunities.  To learn about research funding opportunities from PeDRA, visit the Grants & Awards Page.  

Filed Under: News

Webinar: Overview of the PeDRA Research Toolkit

January 28, 2020 By Jenn Dawson

This presentation includes an overview of the collaborative research process, an overview of the support that PeDRA provides at each stage, and links to external resources intended to help PeDRA Studies get off the ground and succeed.

full toolkit here

Audio Only Below

Filed Under: Archive, Education, Webinars

AAD – VMX

January 1, 2020 By Jenn Dawson

AAD is hosting a virtual meeting experience June 12 – 14, 2020.

Learn more

Filed Under: Events Archive

Webinar: Catalyzing Your Research: From Idea to Action

April 15, 2021 By Jenn Dawson

Live webinar on Tuesday, April 27, 2021 at 5:30 PM PT / 8:30 PM ET. So you’ve got the funding, now how do you make the research happen? Hear from three funded PeDRA investigators and learn how they assembled their teams, tackled the paperwork, and got their projects off the ground. Don’t miss this great opportunity to learn from their experiences!

This program is run in partnership with the Society for Pediatric Dermatology Junior Faculty/Fellows Committee.


Catalyzing Your Research: From Idea to Action
Tuesday, April 27, 5:30 PM PT / 7:30 PM CT / 8:30 PM ET

Hosts: Lisa Arkin, MD and JiaDe Yu, MD
Speakers: Elena Hawryluk, MD, PhD, Lucinda Kohn, MD and Leo Shmuylovich, MD, PhD

register now

Speakers

Elena Hawryluk, MD, PhD

Elena B. Hawryluk, MD, PhD is a board-certified Dermatologist and Pediatric Dermatologist, and Assistant Professor of Dermatology at Harvard Medical School, where she serves as the Faculty Director of Pediatric Dermatology for the Harvard Combined Dermatology Residency Program.  After graduating from Carnegie Mellon University with degrees in Computer Science and Biological Sciences, she completed her medical degree (MD) and PhD (Cell Biology and Molecular Physiology) at the University of Pittsburgh School of Medicine’s Medical Scientist Training Program.  Dr. Hawryluk completed her internship at St. Vincent Hospital, followed by dermatology residency at Harvard Medical School, where she served as a Chief Resident.  Subsequently, she undertook advanced fellowship training in Pediatric Dermatology at Boston Children’s Hospital and was supported by the Dermatology Foundation’s Fellowship in Pediatric Dermatology award.  She serves on committees for the American Academy of Dermatology and Society for Pediatric Dermatology and is the Chair of the American Academy of Dermatology’s Melanoma and Skin Cancer Community Program Committee. Dr. Hawryluk has a clinical interest in pigmented lesions and melanoma, particularly in the pediatric population.  She has authored both primary research and review articles on melanoma and pigmented lesions and has delivered presentations at regional and national meetings on these topics. She has been supported by the Society for Pediatric Dermatology and Pediatric Dermatology Research Alliance’s Weston Career Development Award and the Dermatology Foundation Pediatric Dermatology Career Development Award.

    Lucinda Kohn, MD

    Lucinda Kohn, MD is an Assistant Professor of Dermatology at the University of Colorado, Anschutz Medical Campus and practices pediatric dermatology at the Children’s Hospital of Colorado. Dr. Kohn’s main area of academic interest is focused on increasing access to pediatric dermatology care for all children. She is affiliated with the Centers for American Indian and Alaska Native Health at the Colorado School of Public Health and is particularly focused on addressing disparities in dermatology care in American Indian and Alaska Native populations. Her overall career goal is to develop high quality, ethical, and replicable programs to expand pediatric dermatology to American Indian and Alaska Native youth.

      Leo Smuylovich, MD, PhD

      Dr. Shmuylovich is a Pediatric Dermatologist in the Division of Dermatology and a postdoctoral scholar in the Optical Radiology Laboratory at Washington University in Saint Louis, Missouri. He is at the start of his career as an MD/PhD dermatology physician scientist. His training has included both a Bachelors of Science in Chemical Engineering and a Physics PhD, and inspired by his quantitative background, he is focused on developing novel tools that objectively measure skin disease. The research mission of his lab will be the development technologies that provide all patients with access to accurate diagnosis and management of skin disease and improve treatment outcomes. 

        Filed Under: Education for Researchers

        Virtual Journal Club – April 2021

        April 15, 2021 By Mike Siegel

        Filed Under: Education for Researchers

        PeDRA Invests $149,454 in New Grants and Awards

        April 14, 2021 By Mike Siegel

        April 14, 2021 – Nine investigators or teams have received funding through the 2020 PeDRA Research Grants, Consensus Grant, and Weston Career Development Award (CDA) programs.  Research Grants are given to support early-stage research projects to lay the foundation for larger scale studies in future. The Weston CDA is given to develop the career of a promising clinician scientist through one year of mentored research. Now in its second year, the Consensus Grant is given to support the creation of consensus guidelines, best practice recommendations, or consensus treatment plans for the treatment of diseases in the field of pediatric dermatology.   

        Together, these nine awards represent a contribution of $149,454 and bring PeDRA’s total 2020 investment in projects, initiatives, and investigators to more than $280,000, or almost twice the investment made in 2019, which had been the highest total in PeDRA’s history.   

        Click through the links below to learn more about each of these grants and awards:

        Research Grants

        • Kristen Berrebi, MD from the University of Iowa was awarded $9,850 to pursue a study titled “A Multi-Center Retrospective Cohort Study on the Utility of Ancillary Studies in the Risk Assessment and Management of Spitz Nevi, Atypical Spitzoid Tumors, and Spitzoid Melanoma in the Pediatric Population.”
        • Yvonne Chiu, MD from the Medical College of Wisconsin, together with Co-PI’s Beth Drolet, MD and Michele Ramien, MD, was awarded $15,000 to pursue a study titled “Clinical and Genetic Characterization of Recurrent Reactive Infectious Mucocutaneous Eruption.”
        • Carrie Coughlin, MD from Washington University was awarded $15,000 to pursue a study titled “Beyond the phenotype – A targeted sequencing study to identify the spectrum of genetic mutations in pyogenic granulomas.”
        • Sonia Kamath, MD from the University of Southern California was awarded $15,000 to pursue a study titled “Characterization of the presenting cutaneous manifestations of juvenile dermatomyositis.”
        • Reid Oldenberg, MD, PhD from the University of California San Diego was awarded $15,000 to pursue a study titled “Optimizing Clinical Application of Lymphocyte Activation Tests for the Detection of Causative Medications in severe cutaneous Adverse Reactions.”
        • Antonia Reimer-Taschenbrecker, MD and Co-PI Amy Paller, MD from Northwestern University, were awarded $15,000 to pursue a study titled “Deciphering the “ugly duckling” – Natural history and molecular characterization of epidermolysis bullosa nevi.”
        • Amy Paller, MD and Co-PI Jennifer Boles Scott, MD from Northwestern University were awarded $15,000 to pursue a study titled “TNF inhibitor-induced psoriasiform dermatitis in children: Clinical and mechanistic analyses.”

        Weston Career Development Award
        Supported in partnership with the Society for Pediatric Dermatology

        • Emily Gurnee, MD from the University of Colorado Denver was awarded $40,000 to conduct a one-year project titled “Investigating the role of Staphylococci in Pediatric Skin Disease” under the mentorship of Anna Bruckner, MD.

        Consensus Grant

        • A team led by Lara Wine Lee, MD, PhD from the Medical University of South Carolina were awarded $24,604 to generate guidelines for capillary malformation-arteriovenous malformation syndrome (CM-AVM).

        Applications are currently being accepted for the 2021 Childhood Eczema Challenge Grant with a deadline of May 4, and the next opportunity to apply for a Research Grant, Consensus Grant, or Weston CDA will be December 2021. To learn more about these and other research funding opportunities, visit PeDRA’s Grants & Awards Page.      

        Interested in supporting projects focused on childhood skin diseases through the PeDRA Grants and Awards Program? Click here to donate now or email us to discuss named grant opportunities.

        Filed Under: News

        A Multi-Center Retrospective Cohort Study on the Utility of Ancillary Studies in the Risk Assessment and Management of Spitz Nevi, Atypical Spitzoid Tumors, and Spitzoid Melanoma in the Pediatric Population

        April 13, 2021 By Katherine Devenport



        Principal Investigator:

        Kristen Berrebi, MD
        University of Iowa Health Care

        Overview:

        Spitz tumors are melanocytic proliferations seen in children and are divided into three categories along a spectrum: (1) benign Spitz nevus, (2) atypical Spitz tumor, and (3) Spitzoid melanoma. The current gold standard for diagnosis is biopsy. Identification of Spitzoid melanoma is important because diagnosis and appropriate treatment can prevent morbidity and mortality, but the differentiation between this spectrum of lesions remains a challenge.

        Additional immunohistochemical and molecular/genetic studies have been developed for further characterization of these lesions, however their utility is not well-defined.. Clinical uncertainty arises when benign histopathologic features do not align with results of these studies.

        This study aims to pool data for patients with Spitzoid neoplasms in an effort to evaluate how these aforementioned ancillary studies affect clinical plan and outcome. We hope to identify the value and cost effectiveness of these studies with a future goal of determining treatment guidelines of Spitzoid neoplasms.

        Status:

        This project was funded by a 2020 PeDRA Research Grant.

        Filed Under: Skin Tumors and Reactions to Cancer Therapies

        Clinical and Genetic Characterization of Recurrent Reactive Infectious Mucocutaneous Eruption

        April 13, 2021 By Katherine Devenport




        Principal Investigators:

        Yvonne Chiu, MD
        Medical College of Wisconsin

        Michele Ramien, MD
        University of Calgary

        Beth Drolet, MD
        University of Wisconsin, Madison

        Overview:

        Reactive infectious mucocutaneous eruption (RIME) is a condition activated by an infection, resulting in blisters on the skin and widespread sores on mucous membranes. RIME is rare but most commonly affects children and adolescents. Recurrent RIME, where people have multiple episodes of RIME, is even more rare.

        Recent research studies have shown that genetic differences can affect how children respond to common viral infections. We hypothesize that people who have RIME have genetic differences that cause an abnormal hyper-inflammatory response to common infections, and that people with recurrent RIME have even stronger genetic susceptibility.

        The medical community does not know much about RIME or how to treat it. We would like to characterize RIME and recurrent RIME, describing the clinical features, the immunologic profile, and discovering genetic variants. We hope that if we can understand what makes children have RIME, we will be able to treat the disease more effectively.

        Status:

        This project was funded by a 2020 PeDRA Research Grant.

        Filed Under: Connective Tissue & Autoimmune

        Beyond the phenotype – A targeted sequencing study to identify the spectrum of genetic mutations in pyogenic granulomas

        April 13, 2021 By Katherine Devenport


        Principal Investigator:

        Carrie Coughlin, MD
        Washington University School of Medicine in St. Louis

        Overview:

        Pyogenic granulomas are benign growths of blood vessels which can grow quickly and bleed. It can be difficult to stop the bleeding, which can make them an urgent problem. Their primary treatment is surgical, which carries the risks of infection, scarring, and recurrence. Therefore, understanding the changes that occur in the DNA of these growths may lead to better medicines to treat them and avoid the potential side effects of surgery. In this study, we propose examining the DNA of 60 previously removed pyogenic granulomas to investigate for the presence of spontaneous mutations in 177 different genes which may have caused the formation of these benign growths. These 60 samples will be representative of diversity in age, sex, and location on the body to provide the best profile of DNA mutations to inform the future development of targeted medicines.

        Status:

        This project was funded by a 2020 PeDRA Research Grant.

        Filed Under: Skin Tumors and Reactions to Cancer Therapies

        Deciphering the “ugly duckling” – Natural history and molecular characterization of epidermolysis bullosa nevi

        April 13, 2021 By Katherine Devenport



        Principal Investigators:

        Amy Paller, MD
        Northwestern University
        Feinberg School of Medicine

        Antonia Reimer-Taschenbrecker, MD
        University of Freiburg, Germany
        Northwestern University
        Feinberg School of Medicine

        Overview:

        Epidermolysis bullosa (EB) is a rare genetic skin disease with fragile skin, leading to blisters and wounds after just already minor injury. EB nevi (EBN) are large pigmented spots occurring in up to 14% of EB patients. They grow rapidly and show certain characteristics of melanoma, the most dangerous skin cancer in humans, although they are thought to be benign. Why EBN develop is unclear. It is also unknown whether EBN are, in fact, true nevi and thus carry certain genetic changes in BRAF or NRAS genes with a risk of transformation into cancer. Our goal is to extend the understanding of the course and pathogenesis of EBN by joining patient cohorts of the PeDRA EBCRC group and international reference centers. By analyzing EBN photographs, clinical data, and tissue samples, we aim to better understand how and why EBN develop, as well as their characteristics, allowing more effective longitudinal evaluation.

        Status:

        This project was funded by a 2020 PeDRA Research Grant.

        Filed Under: Genetic Skin Disorders

        Investigating the role of Staphylococci in Pediatric Skin Disease

        April 13, 2021 By Katherine Devenport


        Principal Investigator:

        Emily Gurnee, MD
        University of Colorado Denver

        Overview:

        Staphylococcus aureus is a type of bacteria that commonly causes skin infections. Infections with this type of bacteria may worsen both common and rare skin diseases seen in children. There are several different types of Staphylococci and some may be more likely to cause severe disease than others. We plan to learn more about the relationship between skin disease and the type of bacteria by collecting skin swabs from children with atopic dermatitis, and epidermolysis bullosa, two very different diseases cared for by pediatric dermatologists. We plan to compare how severe these skin diseases are when Staphylococcal bacteria are present, and to investigate how the Staphylococci we find might be causing worsening disease. The purpose of this project is to better understand the relationship between Staphylococcus and pediatric skin disease with the long term goal of better understanding how to treat skin diseases.

        Status:

        This project was funded by a 2020 Weston Career Development Award.

        Filed Under: Cross-cutting Research

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