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Pediatric Dermatology Research Alliance

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Podcasts

Series: Emerging Mechanisms of Action in the Treatment of Moderate-to-Severe Alopecia Areata in Children

April 17, 2021 By Jenn Dawson

Moderate-to-severe alopecia areata (AA) is associated with negative impacts on quality of life and health outcomes in all age groups. However, the impact on children living with this disease and their families is uniquely severe. Children and their families face the daily burden of a chronic disease, exacerbated by bullying and impact on parental mental health that is particularly severe for a disease with such noticeable manifestations. Recent advances in our understanding of the pathobiology underlying AA have contributed to a promising pipeline of therapeutic options for patients in the near future. Yet, apprehension remains over the consequences of systemic treatment of AA, which is all the more significant in the pediatric population. To address the need for better awareness and understanding of AA, and provide a greater depth of knowledge in the mechanisms underlying emerging treatment options for AA, PeDRA is conducting a six-part educational series Emerging Mechanisms of Action in the Treatment of Moderate-to-Severe Alopecia Areata in Children.      

Being hosted by distinguished faculty in pediatric dermatology this non-CME program will include a total of six parts, including three webinars, three podcasts. 


Part 1: ALOPECIA AREATA – A Clinical Overview
PRESENTED LIVE: Wednesday, May 19, 2021, 5:00 – 6:00PM PT / 8:00 – 9:00PM ET

Chairs and Speakers: Leslie Castelo-Soccio MD, PhD and Britt Craiglow, MD

WATCH NOW
Audio Only

Part 2: ALOPECIA AREATA – The Science
PRESENTED LIVE: Wednesday, June 2, 2021, 5:00 – 6:00PM PT / 8:00 – 9:00PM ET

Chairs: Leslie Castelo-Soccio, MD, PhD and Britt Craiglow, MD
Speakers: John O’Shea, MD, and Ali Jabbari, MD, PhD

watch now
Audio Only

Part 3: ALOPECIA AREATA – The Future
PRESENTED LIVE: Wednesday, June 16, 2021, 5:00 – 6:00PM PT / 8:00 – 9:00PM ET

Chairs: Chairs: Leslie Castelo-Soccio, MD, PhD and
Britt Craiglow, MD
Speaker: Rodney Sinclair, MD, MBBS, FACD

watch now
Audio only

Podcast Part 1: ALOPECIA AREATA – A Conversation with Dr. Carolyn Goh

Chairs: Leslie Castelo-Soccio, MD, PhD and Britt Craiglow, MD
Special Guest: Carolyn Goh, MD

Listen now

Podcast Part 2: ALOPECIA AREATA – Ask Me Anything

Chairs: Britt Craiglow, MD and
Leslie Castelo-Soccio, MD, PhD

Listen now

Podcast Part 3: ALOPECIA AREATA – Patient Perspectives

Chairs: Britt Craiglow, MD and
Leslie Castelo-Soccio, MD, PhD
Special Guests: Crystal and Gracie

Listen now

FACULTY

Leslie Castelo-Soccio, MD, PhD

Co-Chair

Dr. Castelo-Soccio is Assistant Professor of Dermatology and Pediatrics at the University of Pennsylvania Perelman School of Medicine and Director of Research in the Section of Dermatology at Children’s Hospital of Philadelphia. She maintains board-certification in dermatology and pediatric dermatology. Dr. Castelo-Soccio is dedicated to patient care and research with a goal of improving quality of life for pediatric patients with skin disease. She has a clinical and academic focus on alopecia, hair conditions and genodermatoses with specialty clinics for both hair and genodermatoses. She has worked on creating tools that can be used in both the clinical and research arenas and has a research interest in the microbiome of alopecia areata. As research director for her section, she additionally supports medical students, residents, fellows and colleagues in many other areas of collaborative research. She has been supported by the Dermatology Foundation and the National Alopecia Areata Foundation. She is an active on the medical advisory board for the National Alopecia Areata Foundation and as a leader of the Hair working group for the Pediatric Dermatology Research Alliance.

    Britt Craiglow, MD

    Co-Chair

    Dr. Craiglow is Adjunct Associate Professor of Dermatology at Yale and sees patients in private practice in Fairfield, CT.  Her clinical areas of expertise include inflammatory dermatoses, alopecia, and inherited disorders of keratinization. She has particular interest in medical therapeutics and health-related quality of life. Dr. Craiglow has been a pioneer in the use of Janus kinase inhibitors for alopecia areata and strong advocate for advancement of therapies for those affected by this often devastating disease.    


      SPECIAL GUESTS

      Ali Jabbari, MD, PhD

      Dr. Jabbari is an Associate Professor of Dermatology at the University of Iowa, where he supervises the resident-staffed Hair Disorders Clinic, serves as a Principal Investigator for the University of Iowa Alopecia Areata Registry, and runs a basic science research laboratory.  The major focus of his work is inflammatory and immunoregulatory pathways in alopecia areata. Dr. Jabbari has received funding from the Dermatology Foundation, the National Institutes of Health, and the Department of Veterans Affairs.

        John O’Shea, MD

        John J. O’Shea graduated Phi Beta Kappa from St. Lawrence University and the University of Cincinnati College of Medicine. He carried out a residency in Internal Medicine at the SUNY-Upstate Medical University and subspecialty training and postdoctoral research at the NIH.  He is currently the Director of the Intramural Research Program at the National Institute of Arthritis and Musculoskeletal and Skin Diseases.  

        Dr. O’Shea has made fundamental discoveries related to the basic mechanisms underlying cytokine signal transduction. He and his colleagues first cloned the human tyrosine kinase JAK3 and discovered its role in signaling by interleukin-2.  These insights led to the discovery of JAK3 mutations as a cause of severe combined immunodeficiency.  This led Dr. O’Shea and his colleagues to propose that targeting JAKs would represent a new class of immunomodulatory drugs and now nine JAK inhibitors been approved for the treatment of multiple forms of arthritis, atopic dermatitis and inflammatory bowel disease.  Dr. O’Shea has made many important insights into the role of STAT family transcription factors and more recently, he has made seminal discoveries related to how STATs impact the epigenome.

        Dr. O’Shea has received numerous awards, including the: NIH Director’s Award four times, USPHS Physician Researcher of the Year Award, Irish Immunology Public Lecture Award, Arthritis Foundation’s Howley Prize, Drake Prize, Ross Prize in Molecular Medicine, the Millstein Prize, the AAI-Steinman Award for Human Immunology and the ASCI Harrington Prize. Dr. O’Shea is a member of the American Society of Clinical Investigation, American Association of Physicians and the National Academy of Medicine and was named a Master of the American College of Rheumatology. He has published more than 330 peer-reviewed articles and is on the editorial boards of Immunity and the Journal of Experimental Medicine. ing soon

          Rodney Sinclair, MD, MBBS, FACD

          Rodney Sinclair is a Professorial Associate in the Department of Medicine at the University of Melbourne, Director of Sinclair Dermatology Institute for Research, Education and Clinical Trials (DIRECT) and Professor/Director of Dermatology at the Epworth Hospital, a 700+ bed, not for profit private hospital in Melbourne. He is co-founder and Past-President of the Australasian Society for Dermatology Research (ASDR), co-founder and Past-President of the Australasian Hair and Wool Research Society (AHWRS) and Past–President of the Skin and Cancer Foundation of Victoria. He is a Board Member of the International Society of Dermatology, the International Academy of Cosmetic Dermatology, the ASDR and AHWRS. He was Professor/Director of Dermatology at St Vincent’s Hospital Melbourne from 2005-2013 and in 2012 was awarded Honorary Life Membership of the American Dermatology Association. Prof Sinclair is Secretary General for the International Congress of Dermatology in Melbourne that will be held in November 2021 and Congress President of the World Congress of Hair Research that will be held in Melbourne in April 2022.  In 2021 he will deliver a plenary lecture at the 101st British Association of Dermatology Annual Scientific Meeting. He has supervised over 15 post-graduate research students and co-established the PhD/FACD program in Australia develop clinician scientists.  Professor Sinclair’s contributions to the medical literature can be viewed at here.

            Carolyn Goh, MD

            Dr. Goh is Associate Clinical Professor of Dermatology at David Geffen School of Medicine at UCLA She practices general medical dermatology with a specialty in hair loss and scalp disorders. She did undergraduate studies at Stanford University with a major in Comparative Studies in Race and Ethnicity with a minor in Human Biology. She completed medical school at Weill Medical College of Cornell University with honors in both research and community service. She did an internship in internal medicine at Harbor-UCLA Medical Center and completed her residency at New York-Presbyterian Hospital/Cornell in New York City. Her research and clinical interests are in all types of hair loss including alopecia areata and scarring alopecia. She has been active with patient advocacy groups and local support groups for patients with hair loss. Additionally, she sees children and adults for all skin disorders including eczema, psoriasis, acne, and skin cancer.


              Special thanks to Pfizer Inc. for their support of this independent medical education program. PeDRA is solely responsible for all program content and the selection of all presenters, authors, moderators, and faculty.

              Filed Under: Education, Podcasts, Series, Town Halls, Webinars

              Series: Emerging Therapies for Moderate-to-Severe Atopic Dermatitis in Children

              September 25, 2020 By Mike Siegel

              Moderate-to-severe atopic dermatitis is associated with negative impacts on quality of life and health outcomes in all age groups, with the impact on children and families being uniquely severe. However, the rapid pace of drug development and uncertainty around novel medications may impact the shared decision-making process and lead to suboptimal treatment of many children. Thus, educating pediatric dermatologists and allergists is critical to positively affect treatment decisions and improve long-term outcomes. In addition, engaging experts in pediatric dermatology and allergy to consider what are the most important research issues in atopic dermatitis is important to direct future efforts. To address this need and help fill the gap left by canceled conferences in 2020, PeDRA is conducting a six-part educational series Emerging Therapies for Moderate-to-Severe Atopic Dermatitis in Children.      

              Being hosted by distinguished faculty in pediatric dermatology and allergy/immunology, this non-CME program will include a total of six parts, including two webinars, two podcasts, and two virtual meetings/townhalls. 


              Part 1: PEDIATRIC ATOPIC DERMATITIS – New and Emerging Systemic Therapies: An Overview
              RECORDED LIVE: Tuesday, October 6, 2020, 5:15 – 6:15PM PDT / 8:15 – 9:15PM EDT

              Chair: Lawrence Eichenfield, MD
              Speakers: Megha Tollefson, MD and Bob Geng, MD
              Panel: Wynnis Tom, MD and Dawn Davis, MD

              View Full Agenda

              5:15 – 5:20 – Introduction
              5:20 – 5:37 – Biologics – Overview and translation to practice
              5:37 – 5:49 – JAK-inhibitors
              5:49 – 6:01 – Mechanisms of action and allergy perspectives
              6:01 – 6:15 – Moderated discussion with audience

              Watch NOW

              Part 2: PEDIATRIC ATOPIC DERMATITIS – Algorithms of the Future
              RECORDED LIVE: Tuesday, October 13, 2020, 5:15 – 6:15PM PDT / 8:15 – 9:15PM EDT

              Chair: Lawrence Eichenfield, MD
              Speakers: Dawn Davis, MD and Wynnis Tom, MD
              Panel: Megha Tollefson, MD and Bob Geng, MD

              View Full Agenda

              5:15 – 5:20 – Introduction
              5:20 – 5:32 – New topicals for moderate to severe disease
              5:32 – 5:42 – New and traditional systemics: where do they fit?
              5:42 – 6:00 – Considerations when selecting appropriate therapy for the appropriate patient
              6:00 – 6:15 – Interactive discussion on “hot” research issues in moderate to severe atopic dermatitis for pediatric dermatologists and allergists

              Watch now

              Part 3: Systemic Therapy for Moderate-to-Severe AD in Children: Where are We?
              AVAILABLE NOW

              Host: Lawrence Eichenfield, MD
              Guests: Dawn Davis, MD, Bob Geng, MD, and Wynnis Tom, MD
              Guests

              LISTEN NOW:

              https://podcasts.captivate.fm/media/42f1f451-4c7a-4c47-adc7-3f8302d68e01/ad-1st-podcast-online-audio-converter.mp3

              Subscribe to PeDRA Podcasts


              Part 4: Systemic Therapy for Moderate-to-Severe AD in Children: Where are We?
              Tuesday, December 8, 2020 5:15 – 6:15PM PST / 8:15 – 9:15PM EST

              Host: Lawrence Eichenfield, MD
              Guests: Dawn Davis, MD, Bob Geng, MD, and Wynnis Tom, MD
              Special Guests: Emma Guttman-Yassky, MD, PhD and Eric Simpson, MD

              LISTEN NOW:

              https://podcasts.captivate.fm/media/5f6ed858-27df-4ec9-906d-ba7e362373c6/ad-where-are-we-town-hall-use-this-one.mp3

              Subscribe to PeDRA Podcasts


              Part 5: Patient Perspectives on Therapies for Moderate-to-Severe AD in Children
              AVAILABLE NOW

              Host: Dawn Davis, MD
              Special Guests: Charlene Miciano and Sarah Pry

              LISTEN NOW:

              https://podcasts.captivate.fm/media/1cdbecd8-cf74-4b2b-ae80-4a4db52f1e88/patient-perspectives-podcast.mp3

              Subscribe to PeDRA Podcasts


              Part 6: Patient Perspectives on Therapies for Moderate-to-Severe AD in Children
              Tuesday, January 5, 2021, 5:15 – 6:15PM PST / 8:15 – 9:15PM EST

              An open discussion with faculty and patient advocates in follow-up to the second podcast. Bring your questions or just listen in.

              Host: Dawn Davis, MD
              Guests: Lawrence Eichenfield, MD, Bob Geng, MD, and Wynnis Tom, MD
              Special Guests: Korey Capozza, MPH from Global Parents for Eczema Research and Wendy Smith Begolka, MBS from the National Eczema Association

              LISTEN NOW:

              https://podcasts.captivate.fm/media/1ddde529-02a1-49c7-9539-5f531f69664f/patient-perspectives-ad-th2final.mp3

              Subscribe to PeDRA Podcast


              FACULTY

              Lawrence Eichenfield, MD

              Chair

              Professor of Dermatology and Pediatrics
              Chief, Pediatric and Adolescent Dermatology
              Vice Chair, Department of Dermatology
              University of California, San Diego and Rady Children’s Hospital, San Diego

                Bob Geng, MD

                Assistant Professor of Medicine and Pediatrics
                Divisions of Adult and Pediatric Allergy & Immunology
                Co-Director of the Allergy Asthma Foundation of America sponsored UCSD Pediatric Severe Asthma Program
                Allergy/Immunology Director of the Multidisciplinary Atopic Dermatitis Program
                University of California, San Diego and Rady Children’s Hospital, San Diego

                  Dawn Davis, MD

                  Professor of Dermatology and Pediatrics
                  Division Chair, Clinical Dermatology
                  Director, Section of Pediatric Dermatology
                  Mayo Clinic Rochester

                    Megha Tollefson, MD

                    Associate Professor of Dermatology and Pediatrics
                    Consultant, Dermatology
                    Consultant, Pediatric and Adolescent Medicine
                    Mayo Clinic Rochester

                      Wynnis Tom, MD

                      Clinical Professor of Dermatology and Pediatrics
                      Fellowship Program Director
                      Pediatric & Adolescent Dermatology
                      University of California, San Diego and Rady Children’s Hospital, San Diego


                        SPECIAL GUESTS

                        Emma Guttman-Yassky, MD, PhD

                        Vice Chair for Research
                        Incoming System Chair of the Kimberly and Eric J. Waldman Department of Dermatology
                        Icahn School of Medicine at Mount Sinai

                          Charlene Miciano

                          Charlene is a college student from San Diego majoring in bioinformatics. Her experience with eczema growing up influenced her to become an ambassador for the National Eczema Association. When she’s not coding, she enjoys music in many forms, whether it be playing piano or ukulele, doing karaoke, or going to concerts.

                            Korey Capozza, MPH

                            Korey is the founder and executive director of Global Parents for Eczema Research and the mother of a child with moderate to severe eczema. Her professional background is in public health, collaborative leadership, and patient-centered research.

                              Eric Simpson, MD

                              Professor of Dermatology
                              Oregon Health and Science University

                                Sarah Pry

                                Sarah is a mother of 2, Aiden age 12 and Bayle age 8. Aiden has severe eczema. Sarah works full time as an insurance agent in TN and in what spare time she has as a mom, she plays with her kids. She also loves to advocate and learn from the experts by volunteering or helping anyway that she can.

                                  Wendy Smith Begolka, MBS

                                  Ms. Smith Begolka is the VP for Scientific and Clinical Affairs for the National Eczema Association (NEA) where she guides the evolution and growth of NEA’s patient-centric research and clinical care efforts across the organization and with diverse stakeholders. Prior to joining NEA in 2018, she conducted biomedical laboratory research investigating immunological pathways of autoimmune disease at Northwestern University, and for over a decade, led the development of American Academy of Dermatology clinical guidelines and the application of science to the intersecting areas of quality, education, and advocacy. Her 25+ year scientific career has focused on advancing research, the use of scientific discovery and findings to support improved therapeutic options and clinical care, and the translation of research data for educational, quality, advocacy, and policy initiatives.


                                    Special thanks to Pfizer Inc. for their support of this independent medical education program.  PeDRA is solely responsible for all program content and the selection of all presenters, authors, moderators, and faculty.

                                    Filed Under: Archive, Education, Podcasts, Series, Town Halls, Webinars

                                    Podcast: A Roadmap for Navigating the New Eczema Treatment Landscape with Dr. Eric Simpson

                                    June 17, 2020 By Mike Siegel

                                    Through a special partnership with Global Parents for Eczema Research (GPER), PeDRA co-hosted a podcast interview with Dr. Eric Simpson from OHSU on June 5, 2020.  The podcast features a roadmap of new and emerging eczema treatments and Q&A with a small group of parents and early career PeDRA investigators.  Listen and share the 25-minute podcast, also available for download on these platforms:

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                                    Filed Under: Archive, Education, For Patients, Podcasts

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