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PeDRA Use of Retinoids in Ichthyosis Work Group Publishes Consensus Recommendations for the use of Retinoids in Children with Disorders of Cornification

November 10, 2020 By Mike Siegel

November 10, 2020 – Under the direction of Andrea Zaenglein, MD of Penn State Health and Moise Levy, MD of Dell Medical School, the Pediatric Dermatology Research Alliance Use of Retinoids in Ichthyosis Work Group has published a consensus manuscript on the use of topical and systemic retinoids for the care of children and adolescents with ichthyosis and other disorders of cornification.  Available as an open access paper on-line in the journal Pediatric Dermatology, the manuscript presents consensus-based recommendations assembled using a modified Delphi process that brought together existing evidence and expert opinion from a group of 24 experts from pediatric dermatology, general dermatology, pediatric cariology, obstetrics-gynecology, bone development, and ophthalmology. Ultimately, the hope is for these recommendations to benefit families living with this rare group of genetic skin diseases through better-informed treatment decisions and improved management of disease.

The manuscript addresses many clinical scenarios and patient-centric considerations, including skin comfort, long-term safety, and shared decision-making.  The Work Group provides a total of 28 consensus statements regarding effects on the skin, topical use, dosing, effects on bone, effects on the eye, effects on lipids and liver, psychiatric effects, contraception, impact of iPLEDGE.  In conclusion, the manuscript touts the effectiveness of systemic retinoids in children and adolescents, while clearly defining a list of 21 practice gaps that remain for future study.    

Explore the PeDRA Publication Page for more on this manuscript, as well as each of PeDRA’s other peer-reviewed publications.    

Filed Under: News

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